Retromer Dysfunction and Neurodegenerative Disease
نویسندگان
چکیده
منابع مشابه
The Retromer Complex and Sorting Nexins in Neurodegenerative Diseases
The retromer complex and associated sorting nexins (SNXs) comprise a critical trafficking machinery which mediates endosomal protein sorting. Retromer and/or SNX dysfunction has been linked to several neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Down’s syndrome (DS). In AD, deficiency of the retromer complex or its cargo proteins impairs endosomal...
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The retromer complex is a protein complex that plays a central role in endosomal trafficking. Retromer dysfunction has been linked to a growing number of neurological disorders. The process of intracellular trafficking and recycling is crucial for maintaining normal intracellular homeostasis, which is partly achieved through the activity of the retromer complex. The retromer complex plays a pri...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2018
ISSN: 1389-2029
DOI: 10.2174/1389202919666171024122809